Bench to bedside: the development of rapamycin and its application to stent restenosis

MeSH terms

• Angioplasty, Balloon, Coronary / adverse effects
• Animals
• Calcineurin Inhibitors
• Carrier Proteins / metabolism
• Cell Cycle Proteins / metabolism
• Cell Division / drug effects
• Cell Movement / drug effects
• Clinical Trials as Topic
• Clopidogrel
• Coronary Artery Disease* / surgery
• Cyclin-Dependent Kinase Inhibitor p27
• Down-Regulation / drug effects
• Graft Occlusion, Vascular / diagnosis
• Graft Occlusion, Vascular / etiology
• Graft Occlusion, Vascular / prevention & control*
• Humans
• Hyperplasia / diagnosis
• Hyperplasia / prevention & control*
• Macromolecular Substances
• Phosphotransferases (Alcohol Group Acceptor)*
• Platelet Aggregation Inhibitors / therapeutic use
• Signal Transduction / drug effects
• Sirolimus / metabolism
• Sirolimus / therapeutic use*
• Stents* / adverse effects
• TOR Serine-Threonine Kinases
• Tacrolimus / pharmacology
• Tacrolimus Binding Protein 1A / metabolism
• Ticlopidine / analogs & derivatives
• Ticlopidine / therapeutic use
• Tumor Suppressor Proteins*
• Tunica Media / drug effects
• Tunica Media / pathology
• Vascular Patency / drug effects