Verbalactone, a new macrocyclic dimer lactone from the roots of Verbascum undulatum with antibacterial activity

P Magiatis; D Spanakis; S Mitaku; E Tsitsa; A Mentis; C Harvala

doi:10.1021/np010025r

Verbalactone, a new macrocyclic dimer lactone from the roots of Verbascum undulatum with antibacterial activity

J Nat Prod. 2001 Aug;64(8):1093-4. doi: 10.1021/np010025r.

Authors

P Magiatis¹, D Spanakis, S Mitaku, E Tsitsa, A Mentis, C Harvala

Affiliation

¹ Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens Panepistimiopolis Zografou, GR-15771 Athens, Greece.

PMID: 11520236
DOI: 10.1021/np010025r

Abstract

A novel macrocyclic dimer lactone, named verbalactone, was isolated from the roots of Verbascum undulatum and exhibited interesting antibacterial activity. It is the first time that 1,7-dioxacyclododecane is reported as the ring system of a natural product. The structure and the absolute stereochemistry of the new compound were determined by spectral methods and chemical correlation.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Chromatography, Thin Layer
Decanoic Acids / chemistry
Decanoic Acids / pharmacology
Enterobacter aerogenes / drug effects
Escherichia coli / drug effects
Greece
Klebsiella pneumoniae / drug effects
Lacticaseibacillus casei / drug effects
Lactones / chemistry
Lactones / isolation & purification*
Lactones / pharmacology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Molecular Conformation
Molecular Structure
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Pseudomonas aeruginosa / drug effects
Salmonella enteritidis / drug effects
Spectrophotometry, Infrared
Staphylococcus aureus / drug effects
Staphylococcus epidermidis / drug effects
Stereoisomerism

Substances

3,5-dihydroxydecanoic acid
Anti-Bacterial Agents
Decanoic Acids
Lactones
verbalactone