Abstract
The levels of macrophage migration inhibitory factor (MIF), a proinflammatory and carcinogenic cytokine, were significantly higher in the sera from patients with hepatocellular carcinoma (HCC; 25.6+/-15.3 ng/ml, n=55) and liver cirrhosis (LC; 18.9+/-10.7 ng/ml, n=26) compared with sera from patients with gastrointestinal cancer (6.8+/-7.5 ng/ml, n=29) and normal controls (5.6+/-1.2 ng/ml, n=45; P<0.01). Hepatocytes from patients with LC and HCC, but not from chronic hepatitis, expressed very high levels of MIF. A possible association between overexpression of MIF and hepatocarcinogenesis is suggested.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Carcinoma, Hepatocellular / blood*
-
Carcinoma, Hepatocellular / etiology
-
Carcinoma, Hepatocellular / pathology
-
Cells, Cultured
-
Female
-
Gastrointestinal Neoplasms / blood
-
Hepatitis, Chronic / blood
-
Hepatocytes / metabolism
-
Humans
-
Immunohistochemistry
-
Leukocytes, Mononuclear / metabolism
-
Liver Cirrhosis / blood*
-
Liver Cirrhosis / pathology
-
Liver Neoplasms / blood*
-
Liver Neoplasms / etiology
-
Liver Neoplasms / pathology
-
Macrophage Migration-Inhibitory Factors / biosynthesis
-
Macrophage Migration-Inhibitory Factors / blood*
-
Male
-
Middle Aged
Substances
-
Macrophage Migration-Inhibitory Factors