Macrophage migration inhibitory factor in hepatocellular carcinoma and liver cirrhosis; relevance to pathogenesis

Cancer Lett. 2001 Oct 10;171(2):125-32. doi: 10.1016/s0304-3835(01)00606-1.

Abstract

The levels of macrophage migration inhibitory factor (MIF), a proinflammatory and carcinogenic cytokine, were significantly higher in the sera from patients with hepatocellular carcinoma (HCC; 25.6+/-15.3 ng/ml, n=55) and liver cirrhosis (LC; 18.9+/-10.7 ng/ml, n=26) compared with sera from patients with gastrointestinal cancer (6.8+/-7.5 ng/ml, n=29) and normal controls (5.6+/-1.2 ng/ml, n=45; P<0.01). Hepatocytes from patients with LC and HCC, but not from chronic hepatitis, expressed very high levels of MIF. A possible association between overexpression of MIF and hepatocarcinogenesis is suggested.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Hepatocellular / blood*
  • Carcinoma, Hepatocellular / etiology
  • Carcinoma, Hepatocellular / pathology
  • Cells, Cultured
  • Female
  • Gastrointestinal Neoplasms / blood
  • Hepatitis, Chronic / blood
  • Hepatocytes / metabolism
  • Humans
  • Immunohistochemistry
  • Leukocytes, Mononuclear / metabolism
  • Liver Cirrhosis / blood*
  • Liver Cirrhosis / pathology
  • Liver Neoplasms / blood*
  • Liver Neoplasms / etiology
  • Liver Neoplasms / pathology
  • Macrophage Migration-Inhibitory Factors / biosynthesis
  • Macrophage Migration-Inhibitory Factors / blood*
  • Male
  • Middle Aged

Substances

  • Macrophage Migration-Inhibitory Factors