Abstract
Cisplatin is an agent used in the treatment of distinct oncologic diseases. We present the electrooculographic (EOG) findings of 6 patients which were seen at our Department under the diagnosis of chronic toxicity for cisplatin and associated vestibular alterations. Mean of age was 45 years. Three subjects were female (50%). The most frequent pathologic finding was ataxic pursuit tracking (100%). Additionally, spontaneous nystagmus, alterations in positional test, and vestibulo-ocular reflex suppression were also found. These results are discussed and the main literature concerning this matter is reviewed.
MeSH terms
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Adolescent
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Adult
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Aged
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Antineoplastic Agents / adverse effects*
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Cisplatin / adverse effects*
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Female
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Humans
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Male
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Middle Aged
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Nystagmus, Optokinetic
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Nystagmus, Pathologic / chemically induced
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Nystagmus, Pathologic / diagnosis
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Oculomotor Nerve Diseases / chemically induced*
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Oculomotor Nerve Diseases / diagnosis
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Oculomotor Nerve Diseases / physiopathology
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Reflex, Abnormal / physiology
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Reflex, Vestibulo-Ocular / physiology*
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Retrospective Studies
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Saccades / physiology
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Vestibular Diseases / chemically induced*
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Vestibular Diseases / diagnosis
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Vestibular Diseases / physiopathology
Substances
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Antineoplastic Agents
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Cisplatin