Abstract
[structure: see text]. Isolation and structure elucidation of two novel cyclic tetrapeptides that show a variety of potent antiprotozoal activities by reversibly inhibiting HDAC have been reported. These are the new members of a unique family of cyclic tetrapeptides that do not require the electrophilic alpha-epoxyketone moiety of HC-toxin, trapoxin A, or chlamydocin for their potent activities against HDAC and the malarial parasite.
MeSH terms
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Amino Acid Substitution
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Animals
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Antiprotozoal Agents / chemistry*
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Antiprotozoal Agents / pharmacology
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Eimeria tenella / drug effects
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Histone Deacetylase Inhibitors
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Histone Deacetylases / metabolism*
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Parasitic Sensitivity Tests
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / pharmacology
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Proline / chemistry
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Sarcocystidae / drug effects
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Valine / chemistry
Substances
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Antiprotozoal Agents
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Histone Deacetylase Inhibitors
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Peptides, Cyclic
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apicidin
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Proline
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Histone Deacetylases
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Valine