Abstract
Over the past year, significant new insights have been gained in our understanding of the lineage determination of red blood cells. In particular, evidence has emerged demonstrating that cross-antagonism of lineage-specific transcription factors plays an important role in determining cell phenotype by actively repressing alternate lineage gene programs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Carrier Proteins / metabolism
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Cell Differentiation
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Cell Lineage*
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DNA-Binding Proteins / metabolism
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Erythroid-Specific DNA-Binding Factors
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Hematopoiesis / genetics*
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / metabolism*
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Humans
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Nuclear Proteins / metabolism
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Proto-Oncogene Proteins / metabolism
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Trans-Activators / metabolism
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Transcription Factors / metabolism*
Substances
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Carrier Proteins
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DNA-Binding Proteins
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Erythroid-Specific DNA-Binding Factors
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Nuclear Proteins
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Proto-Oncogene Proteins
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Trans-Activators
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Transcription Factors
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ZFPM1 protein, human
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proto-oncogene protein Spi-1