Abstract
Scoparinol, a diterpene, isolated from Scoparia dulcis showed significant analgesic (p < 0.001) and anti-inflammatory activity (p < 0.01) in animals. A sedative action of scoparinol was demonstrated by a marked potentiation of pentobarbital-induced sedation with a significant effect on both onset and duration of sleep (p < 0.05). Measurement of urine volume after administration of scoparinol indicated its significant diuretic action.
MeSH terms
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Algorithms
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Analgesics / isolation & purification
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Analgesics / pharmacology*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Asia
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Carrageenan
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Diuretics / isolation & purification
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Diuretics / pharmacology*
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Edema / chemically induced
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Edema / prevention & control
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Hypnotics and Sedatives / pharmacology
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Mice
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Pentobarbital / pharmacology
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Plants, Medicinal / chemistry*
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Rats
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Rats, Long-Evans
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Sleep / drug effects
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Diuretics
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Hypnotics and Sedatives
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Carrageenan
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Pentobarbital