Abstract
Diffuse reflectance laser flash photolysis has been used in an attempt to measure transient triplet spectra of the sensitisers, disulphonated aluminium phthalocyanine and porphyrin IX (derived from 5-amino laevulinic acid), in opaque tissue and models. The latter consisted of tissue phantoms; the former included rat liver and red blood cells. In all cases, triplet-triplet absorption spectra with relatively poor signal-to-noise were obtained providing some encouragement in the application of this technique to in vivo studies on photosensitisers.
MeSH terms
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Aminolevulinic Acid / administration & dosage
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Aminolevulinic Acid / metabolism
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Animals
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Erythrocytes / drug effects
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Erythrocytes / metabolism*
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Indoles / administration & dosage
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Indoles / chemistry
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Indoles / metabolism*
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Liver / drug effects
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Liver / metabolism*
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Male
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Molecular Structure
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Organometallic Compounds / administration & dosage
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism*
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Photolysis
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Photosensitizing Agents / administration & dosage
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / metabolism*
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Rats
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Rats, Wistar
Substances
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Indoles
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Organometallic Compounds
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Photosensitizing Agents
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aluminum phthalocyanine disulfonate
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Aminolevulinic Acid