Magnetic resonance imaging of myocardial perfusion in single-vessel coronary artery disease: implications for transmural assessment of myocardial perfusion

J Cardiovasc Magn Reson. 2000;2(3):189-200. doi: 10.3109/10976640009146567.

Abstract

The purpose of the study was to investigate the potential of magnetic resonance imaging (MRI) to assess transmural differences in myocardial perfusion. Contrast-enhanced MRI was performed at rest and during hyperemia in a dog model and in 22 patients with single-vessel coronary artery disease. From MR signal intensity-versus-time curves, three perfusion parameters were derived: maximum myocardial contrast enhancement (MCE), slope, and inverse mean transit time (1/MTT). In dogs, MCE correlated well (r = 0.87, p < 0.00001) with microsphere-assessed myocardial blood flow. In the patients, the subendocardial MCE decreased during hyperemia (0.89 +/- 0.18 vs. 0.74 +/- 0.15, p < 0.003) and was lower in subendocardium than in subepicardium (0.74 +/- 0.15 vs. 0.84 +/- 0.21, p < 0.02). Parameters slope and 1/MTT paralleled MCE. Contrast-enhanced MRI reflects the transmural redistribution of myocardial perfusion during hyperemia. Perfusion abnormalities can be identified most distinctly in subendocardial myocardium.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Blood Flow Velocity / physiology
  • Contrast Media
  • Coronary Angiography
  • Coronary Circulation / physiology
  • Coronary Disease / diagnosis*
  • Coronary Disease / physiopathology*
  • Dogs
  • Female
  • Gadolinium DTPA
  • Humans
  • Image Processing, Computer-Assisted
  • Least-Squares Analysis
  • Linear Models
  • Magnetic Resonance Imaging / methods*
  • Male
  • Microspheres
  • Middle Aged

Substances

  • Contrast Media
  • Gadolinium DTPA