Abstract
We report the long-term outcome of 27 HIV-infected patients treated for over 3 years with IL-2 and binucleoside analogues. These patients experienced a sustained increase in CD4 cells and a decrease of proviral DNA with infrequent IL-2 cycles. In three cases, virus could not be isolated from activated peripheral cells. A high frequency of HIV-1-specific memory CD4 T cells was found in the patients studied. IL-2 maintains specific effector cells and reduces the pool of infected cells in patients, albeit treated only with binucleosides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / therapeutic use*
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / immunology
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DNA, Viral / blood
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Didanosine / therapeutic use
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Drug Therapy, Combination
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HIV Infections / drug therapy*
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HIV Infections / immunology
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HIV Infections / virology
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HIV-1 / physiology*
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Humans
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Immunologic Memory
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Interleukin-2 / therapeutic use*
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Reverse Transcriptase Inhibitors / therapeutic use
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Time Factors
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Zidovudine / therapeutic use
Substances
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Anti-HIV Agents
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DNA, Viral
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Interleukin-2
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Reverse Transcriptase Inhibitors
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Zidovudine
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Didanosine