Abstract
Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Cells, Cultured
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Drug Evaluation, Preclinical
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Flavonoids / chemistry*
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Humans
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Hydrangeaceae / chemistry*
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Molecular Structure
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Plasmodium falciparum / drug effects
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Spectrometry, Mass, Fast Atom Bombardment
Substances
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Antimalarials
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Flavonoids
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Glycosides