Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity

A Brancale; C McGuigan; B Algain; P Savy; R Benhida; J L Fourrey; G Andrei; R Snoeck; E De Clercq; J Balzarini

doi:10.1016/s0960-894x(01)00471-1

Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2507-10. doi: 10.1016/s0960-894x(01)00471-1.

Authors

A Brancale¹, C McGuigan, B Algain, P Savy, R Benhida, J L Fourrey, G Andrei, R Snoeck, E De Clercq, J Balzarini

Affiliation

¹ Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, CF10 3XF, Cardiff, UK.

PMID: 11549457
DOI: 10.1016/s0960-894x(01)00471-1

Abstract

Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family are herein reported. The compounds retain full antiviral potency in comparison to the furo parent.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Cells, Cultured
Cytomegalovirus / drug effects
Drug Design
Drug Evaluation, Preclinical
Herpesviridae / drug effects*
Herpesvirus 1, Human / drug effects
Herpesvirus 2, Human / drug effects
Humans
Nucleosides / chemistry
Pyrimidines / chemistry*
Pyrimidines / pharmacology*
Structure-Activity Relationship
Thiophenes / chemistry*
Thiophenes / pharmacokinetics*

Substances

Antiviral Agents
Nucleosides
Pyrimidines
Thiophenes