Abstract
We identified two cases of chronic active hepatitis with liver fibrosis induced by lipid lowering drugs of the statin and fibrate classes despite regular monitoring of transaminases. There are few reports of clinically significant hepatitis induced by these drugs and even fewer cases of fibrosis. Given the growing use of these drugs, there are implications for monitoring patients on long-term therapy for liver damage.
Publication types
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Case Reports
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Comparative Study
MeSH terms
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Adult
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Anticholesteremic Agents / administration & dosage
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Anticholesteremic Agents / adverse effects*
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Biopsy, Needle
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Chemical and Drug Induced Liver Injury / diagnosis*
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Chemical and Drug Induced Liver Injury / pathology
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Female
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Hepatitis, Chronic / diagnosis*
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Hepatitis, Chronic / pathology
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Humans
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Liver / pathology
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Liver Cirrhosis / chemically induced*
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Liver Cirrhosis / diagnosis
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Liver Cirrhosis / pathology
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Liver Function Tests
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Male
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Middle Aged
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Structure-Activity Relationship