Abstract
A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var. japonicum, together with pratorimine (2), lycorine (3) and 4'-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4,5-etheno-9,10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells.
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / pharmacology*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Chromatography, Liquid
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Female
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Indicators and Reagents
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Japan
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Neoplasm Transplantation
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Neoplasms, Experimental / drug therapy
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Phenanthrenes / chemistry
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Phenanthrenes / pharmacology*
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Indicators and Reagents
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Phenanthrenes
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criasiaticidine A