Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users

Clin Infect Dis. 2001 Nov 1;33(9):1595-7. doi: 10.1086/322519. Epub 2001 Sep 24.

Abstract

Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.

MeSH terms

  • Adult
  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / pharmacokinetics*
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / pharmacokinetics*
  • Drug Antagonism
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV-1 / drug effects*
  • Humans
  • Male
  • Methadone / administration & dosage
  • Methadone / pharmacokinetics*
  • Middle Aged
  • Narcotic Antagonists / administration & dosage
  • Narcotic Antagonists / pharmacokinetics
  • Nevirapine / administration & dosage
  • Nevirapine / pharmacokinetics*
  • Practice Guidelines as Topic
  • Reverse Transcriptase Inhibitors / administration & dosage
  • Reverse Transcriptase Inhibitors / pharmacokinetics*
  • Substance Abuse, Intravenous / complications*
  • Substance Abuse, Intravenous / drug therapy

Substances

  • Analgesics, Opioid
  • Anti-HIV Agents
  • Narcotic Antagonists
  • Reverse Transcriptase Inhibitors
  • Nevirapine
  • Methadone