[Microalbuminuria, pulse wave velocity and common carotid artery intima-media thickness in type 2 diabetes]

Arch Mal Coeur Vaiss. 2001 Aug;94(8):795-8.
[Article in French]

Abstract

The aim of the study was to evaluate pulse wave velocity (PWV) and carotid intima-media thickness (IMT) in type 2 diabetics with microalbuminuria (mualb). The study concerned 37 patients type 2 diabetics, age: 53.4 +/- 6.6, years free of cardiovascular complications. HbA1C was 7.73 +/- 1.39%, waist circumference 104.2 +/- 11.7 cm. 19 patients with BP > 130/85 mmHg were identified as mild hypertensives (17/19 under treatment). All patients underwent ABPM, PWV and IMT measurements. The study population was separated into 2 subgroups according to median of mualb (mg/24 h): 18.9. [table: see text] In patients with mualb > 18.9 mg/24, IMT and PWV were significantly increased (p = 0.06; p < 0.01). After adjustment to BP and age, there was no significant difference in IMT and PWV in the subgroups. In this selected population of type 2 diabetics, microalbuminuria appears associated to a pressure-dependant vascular remodeling.

Publication types

  • English Abstract

MeSH terms

  • Albuminuria / etiology*
  • Albuminuria / pathology
  • Carotid Arteries / anatomy & histology*
  • Diabetes Mellitus, Type 2 / complications*
  • Female
  • Humans
  • Hypertension / complications
  • Hypertension / etiology*
  • Male
  • Middle Aged
  • Tunica Intima / anatomy & histology*
  • Tunica Intima / pathology
  • Ventricular Remodeling