Abstract
Lipopolysaccharide (LPS) of Gram-negative bacteria and several surface components of Gram-positive bacteria utilize CD14 and CD11a/18 as cellular receptors to induce expression and release of cytokines. Of the surface components of Gram-negative bacteria, porins exhibit a biological activity similar to that of LPS. The results in this paper show that the mechanism of stimulation by porins of THP-1 cells enriched in CD14 receptor after treatment with 1,25-dihydroxyvitamin D(3) (vitamin D(3)) is independent of this receptor, but is partially dependent on CD11a/18 integrins.
MeSH terms
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CD18 Antigens / metabolism*
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Cell Line
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Cytokines / metabolism*
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Humans
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Interleukin-1 / metabolism
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Interleukin-8 / metabolism
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Lipopolysaccharide Receptors / metabolism*
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Lipopolysaccharides / immunology
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Lymphocyte Function-Associated Antigen-1 / metabolism*
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Monocytes / immunology
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Porins / physiology*
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Receptors, Cell Surface / metabolism
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Salmonella typhimurium / immunology
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Salmonella typhimurium / physiology*
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Serotyping
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Tumor Necrosis Factor-alpha / metabolism
Substances
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CD18 Antigens
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Cytokines
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Interleukin-1
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Interleukin-8
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Lipopolysaccharide Receptors
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Lipopolysaccharides
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Lymphocyte Function-Associated Antigen-1
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Porins
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Receptors, Cell Surface
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Tumor Necrosis Factor-alpha