Abstract
Endothelial cells in blood vessels are known to be important during the later stages of organ development in the embryo. However, their involvement at the induction stage of organ formation has not been previously documented. As Bahary and Zon explain in their Perspective, new work demonstrates that endothelial cells secrete factors early in development that induce embryonic endoderm to become liver or pancreas (Matsumoto et al., Lammert et al.).
MeSH terms
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Animals
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Aorta / embryology
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Aorta / physiology
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Basic Helix-Loop-Helix Transcription Factors
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Cell Differentiation
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Culture Techniques
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Embryonic Induction*
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Endoderm / physiology*
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Endothelial Growth Factors / genetics
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Endothelium, Vascular / cytology
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Endothelium, Vascular / embryology
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Endothelium, Vascular / physiology*
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Eye Proteins
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Gene Expression Regulation, Developmental
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Hepatocyte Growth Factor / physiology
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Hepatocytes / cytology
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Insulin / biosynthesis
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Insulin / genetics
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Islets of Langerhans / blood supply
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Islets of Langerhans / cytology
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Islets of Langerhans / embryology*
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Kidney / embryology
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Liver / cytology
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Liver / embryology*
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Lymphokines / genetics
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Mice
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Mice, Transgenic
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Mitogens / genetics
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Mitogens / physiology
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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PAX6 Transcription Factor
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Paired Box Transcription Factors
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Pancreas / blood supply
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Pancreas / cytology
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Pancreas / embryology*
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor Protein-Tyrosine Kinases / physiology
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Receptors, Growth Factor / genetics
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Receptors, Growth Factor / physiology
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Receptors, Vascular Endothelial Growth Factor
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Repressor Proteins
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Signal Transduction
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
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Vascular Endothelial Growth Factors
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Xenopus
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Endothelial Growth Factors
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Eye Proteins
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Homeodomain Proteins
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Insulin
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Lymphokines
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Mitogens
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Nerve Tissue Proteins
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PAX6 Transcription Factor
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Paired Box Transcription Factors
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Pax6 protein, mouse
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Receptors, Growth Factor
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Repressor Proteins
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Trans-Activators
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
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Vascular Endothelial Growth Factors
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pancreatic and duodenal homeobox 1 protein
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Neurogenic differentiation factor 1
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Hepatocyte Growth Factor
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Receptor Protein-Tyrosine Kinases
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Receptors, Vascular Endothelial Growth Factor