Correlation between 99mTc-pertechnetate uptakes and expressions of human sodium iodide symporter gene in breast tumor tissues

D H Moon; S J Lee; K Y Park; K K Park; S H Ahn; M S Pai; H Chang; H K Lee; I M Ahn

doi:10.1016/s0969-8051(01)00243-8

Correlation between 99mTc-pertechnetate uptakes and expressions of human sodium iodide symporter gene in breast tumor tissues

Nucl Med Biol. 2001 Oct;28(7):829-34. doi: 10.1016/s0969-8051(01)00243-8.

Authors

D H Moon¹, S J Lee, K Y Park, K K Park, S H Ahn, M S Pai, H Chang, H K Lee, I M Ahn

Affiliation

¹ Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. [email protected]

PMID: 11578905
DOI: 10.1016/s0969-8051(01)00243-8

Abstract

We investigated a correlation between the expression of human sodium iodide symporter (hNIS) mRNA and the uptake of 99mTc-pertechnetate in 25 breast tumors. 99mTc-pertechnetate scintigraphy revealed positive uptake in 4 patients. The normalized mRNA expression of hNIS was higher in tumors with positive uptake on the scintigraphy (n=4, median 0.97, range 0.78-1.27) than that in negative uptake tumors (n=21, median 0.46, range 0.10-1.03, p < 0.005). 99mTc-pertechnetate uptake is correlated with the hNIS expression in the breast tumor.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / diagnostic imaging*
Breast Neoplasms / genetics
Breast Neoplasms / metabolism*
Female
Gene Expression Regulation, Neoplastic*
Humans
Middle Aged
RNA, Messenger / biosynthesis
Radionuclide Imaging
Radiopharmaceuticals / pharmacokinetics*
Reverse Transcriptase Polymerase Chain Reaction
Sodium Pertechnetate Tc 99m / pharmacokinetics*
Symporters / biosynthesis
Symporters / metabolism*

Substances

RNA, Messenger
Radiopharmaceuticals
Symporters
sodium-iodide symporter
Sodium Pertechnetate Tc 99m