[Effect of human recombinant granulocyte colony-stimulating factor on mouse hematopoietic and lymphoid organs]

G V Karpova; T I Fomina; E A Timina; E V Abramova; V I Masycheva; N M Pustoshilova

[Effect of human recombinant granulocyte colony-stimulating factor on mouse hematopoietic and lymphoid organs]

Eksp Klin Farmakol. 2001 Jul-Aug;64(4):31-3.

[Article in Russian]

Authors

G V Karpova¹, T I Fomina, E A Timina, E V Abramova, V I Masycheva, N M Pustoshilova

Affiliation

¹ Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.

PMID: 11589105

Abstract

Experiments on intact CBA/CALac mice demonstrated that single (1.25 mg/kg) and repeated (0.125 and 1.25 mg/kg, 30 days) injections of recombinant human granulocyte colony stimulation factor lead to reversible dose-dependent granulocyte lineage hyperplasia in bone marrow, regenerative neutrophilic leukocytosis, and thrombocytosis in peripheric blood and to splenic granulo-, erythro-, and thrombocytopoiesis more expressed in males.

Publication types

English Abstract

MeSH terms

Animals
Bone Marrow Cells / cytology
Bone Marrow Cells / drug effects*
Female
Granulocyte Colony-Stimulating Factor / pharmacology*
Hematopoiesis / drug effects*
Humans
Leukocyte Count
Lymphoid Tissue / drug effects*
Male
Mice
Mice, Inbred CBA
Organ Size
Recombinant Proteins
Sex Factors
Spleen / cytology
Spleen / drug effects
Thymus Gland / drug effects

Substances

Recombinant Proteins
Granulocyte Colony-Stimulating Factor