New ammonia equivalents for the Pd-catalyzed amination of aryl halides

Org Lett. 2001 Oct 18;3(21):3417-9. doi: 10.1021/ol0166808.

Abstract

[reaction: see text]. LiN(SiMe3)2, Ph3SiNH2, and LiNH2 can be be used as ammonia equivalents for the Pd-catalyzed coupling of aryl halides. Using these amine derivatives, simple anilines, including ortho-substituted ones, as well as di- and triarylamines can be readily prepared.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amination
  • Amines / chemical synthesis*
  • Ammonia / chemistry
  • Aniline Compounds / chemical synthesis*
  • Benzene Derivatives / chemistry
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Halogens / chemistry
  • Palladium / chemistry

Substances

  • Amines
  • Aniline Compounds
  • Benzene Derivatives
  • Halogens
  • Palladium
  • Ammonia