Abstract
The human oligophrenin-1 gene is ubiquitously expressed at low levels and expressed at high levels in the developing neuroepithelium of the neural tube. Mutations in this gene have been related to the X-linked mental retardation. Using cDNA microarrays, we found evidence that oligophrenin-1 is strongly up-regulated in colorectal tumors. Semiquantitative reverse transcriptase polymerase chain reaction confirmed this finding. Thus, a well-known nervous system-associated human gene transcript may also be an important colorectal tumor marker and potential therapeutic target.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers, Tumor
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Colorectal Neoplasms / metabolism*
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Cytoskeletal Proteins*
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DNA, Complementary / metabolism*
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GTPase-Activating Proteins*
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Humans
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Mutation
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Nuclear Proteins / biosynthesis*
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Nuclear Proteins / genetics
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Oligonucleotide Array Sequence Analysis / methods*
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Phosphoproteins / biosynthesis*
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Phosphoproteins / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Up-Regulation
Substances
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Biomarkers, Tumor
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Cytoskeletal Proteins
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DNA, Complementary
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GTPase-Activating Proteins
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Nuclear Proteins
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OPHN1 protein, human
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Phosphoproteins