Synthesis and Reactions of 3-(Nosyloxy)-2-keto Esters

J Org Chem. 1997 Apr 18;62(8):2458-2465. doi: 10.1021/jo962206h.

Abstract

A series of 3-(nosyloxy)-2-keto esters 7a-j were prepared from the corresponding alpha-keto esters by conversion to the trimethylsilyl enol ether and reaction with p-nitrobenzenesulfonyl peroxide. Conversion of these materials to 1,2,3-trifunctionalized compounds is described, and comparison of their properties with isomeric 2-(nosyloxy)-3-keto esters is discussed.