Abstract
The clinical significance of angiogenesis was investigated in Borrmann type IV gastric cancer. Tumors with high microvessel density (MVD) often metastasized to the liver and lymph nodes. A significant correlation was recognized between macrophage infiltration and MVD. However, MVD was not a prognostic factor. Peritoneal dissemination was a prognostic factor in Borrmann type IV gastric cancer. Thus, angiogenesis plays an important role in the metastasis, but not prognosis in Borrmann type IV gastric cancer.
MeSH terms
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Aged
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Antigens, CD / analysis
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Antigens, Differentiation, Myelomonocytic / analysis
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Biomarkers / analysis
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Endothelial Growth Factors / analysis
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Female
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Humans
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Lymphokines / analysis
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Macrophages / pathology*
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Male
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Middle Aged
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Neovascularization, Pathologic*
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Peritoneal Neoplasms / pathology
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Peritoneal Neoplasms / secondary
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Platelet Endothelial Cell Adhesion Molecule-1 / analysis
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Prognosis
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Stomach Neoplasms / blood supply*
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Stomach Neoplasms / pathology
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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Biomarkers
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CD68 antigen, human
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Endothelial Growth Factors
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Lymphokines
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Platelet Endothelial Cell Adhesion Molecule-1
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors