Sequence polymorphism in the rrs gene of Mycobacterium tuberculosis is deeply rooted within an evolutionary clade and is not associated with streptomycin resistance

T C Victor; A van Rie; A M Jordaan; M Richardson; G D van Der Spuy; N Beyers; P D van Helden; R Warren

doi:10.1128/JCM.39.11.4184-4186.2001

Sequence polymorphism in the rrs gene of Mycobacterium tuberculosis is deeply rooted within an evolutionary clade and is not associated with streptomycin resistance

J Clin Microbiol. 2001 Nov;39(11):4184-6. doi: 10.1128/JCM.39.11.4184-4186.2001.

Authors

T C Victor¹, A van Rie, A M Jordaan, M Richardson, G D van Der Spuy, N Beyers, P D van Helden, R Warren

Affiliation

¹ MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Stellenbosch, South Africa. [email protected]

Abstract

A mutation (C-to-T transition) at position 491 of the rrs gene was identified in a Mycobacterium tuberculosis strain family (n = 208 isolates) that was predominant in a suburb of Cape Town, South Africa. This nucleotide change is not involved in streptomycin resistance, and we suggest caution in assuming that all mutations in genes targeted by antituberculosis drugs confer drug resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antitubercular / pharmacology*
Bacterial Proteins / genetics*
Drug Resistance, Bacterial / genetics*
Evolution, Molecular
Genes, Bacterial*
Humans
Mutation
Mycobacterium tuberculosis / classification
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / genetics
Polymorphism, Genetic / genetics*
Polymorphism, Restriction Fragment Length
Streptomycin / pharmacology*
Tuberculosis, Pulmonary / microbiology

Substances

Antibiotics, Antitubercular
Bacterial Proteins
Streptomycin