Translocation t(4; 6)(q21; q27) in a case of primary thrombocythaemia in transformation

Clin Lab Haematol. 2001 Aug;23(4):259-60. doi: 10.1046/j.1365-2257.2001.00398.x.

Abstract

We report a case of primary thrombocythaemia showing a translocation t(4; 6)(q21; q27) five years after diagnosis. The patient had been treated with hydroxyurea. The clinical picture at the time was consistent with transformation. Karyotypic abnormalities are rare in this disease and are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Cell Transformation, Neoplastic / genetics*
  • Chromosomes, Human, Pair 4*
  • Chromosomes, Human, Pair 6*
  • Fatal Outcome
  • Female
  • Humans
  • Hydroxyurea / administration & dosage
  • Karyotyping
  • Thrombocythemia, Essential / drug therapy
  • Thrombocythemia, Essential / genetics*
  • Translocation, Genetic*

Substances

  • Hydroxyurea