Abstract
Regeneration and tolerance factor (RTF) is a protein with immunosuppressive activity and is normally present in the thymus and placenta. RTF was measured in the livers of patients with regenerating nodules due to alcoholic cirrhosis and hepatitis C. RTF was expressed in the regenerating nodules of 26 patients with alcoholic cirrhosis. All patients with chronic hepatitis C without cirrhosis failed to express RTF. Flow cytometry revealed upregulation of RTF on the lymphocytes from alcoholic cirrhosis and downregulation in hepatitis C disease.
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Antigens, CD*
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Antigens, Differentiation / analysis
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Flow Cytometry
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HLA-DR Antigens / analysis
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Hepatitis C, Chronic / immunology
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Hepatitis C, Chronic / metabolism
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Hepatocytes / chemistry
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Hepatocytes / metabolism*
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Humans
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Immunohistochemistry
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Liver Cirrhosis, Alcoholic / immunology*
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Liver Cirrhosis, Alcoholic / metabolism*
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Membrane Glycoproteins
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NAD+ Nucleosidase / analysis
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Pregnancy Proteins / analysis
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Pregnancy Proteins / biosynthesis*
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Suppressor Factors, Immunologic / analysis
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Suppressor Factors, Immunologic / biosynthesis*
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T-Lymphocytes / chemistry
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T-Lymphocytes / metabolism*
Substances
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Antigens, CD
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Antigens, Differentiation
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HLA-DR Antigens
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Membrane Glycoproteins
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Pregnancy Proteins
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Regeneration and tolerance factor, human
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Suppressor Factors, Immunologic
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ADP-ribosyl Cyclase
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CD38 protein, human
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NAD+ Nucleosidase
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ADP-ribosyl Cyclase 1