Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter?

Blood. 2001 Nov 15;98(10):2900-8. doi: 10.1182/blood.v98.10.2900.

Abstract

Hematopoietic stem cells from 4 different sources have been or are being used for the reconstitution of lymphohematopoietic function after myeloablative, near-myeloablative, or nonmyeloablative treatment. Bone marrow (BM)-derived stem cells, introduced by E. D. Thomas in 1963, are considered the classical stem cell source. Fetal liver stem cell transplantation has been performed on a limited number of patients with aplastic anemia or acute leukemia, but only transient engraftment has been demonstrated. Peripheral blood as a stem cell source was introduced in 1981, and cord blood was introduced as a source in 1988. The various stem cell sources differ in their reconstitutive and immunogenic characteristics, which are based on the proportion of early pluripotent and self-renewing stem cells to lineage-committed late progenitor cells and on the number and characteristics of accompanying "accessory cells" contained in stem cell allografts.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Blood Cells / transplantation
  • Bone Marrow Transplantation* / adverse effects
  • Bone Marrow Transplantation* / mortality
  • Chronic Disease
  • Fetal Blood / cytology
  • Filgrastim
  • Follow-Up Studies
  • Graft Survival
  • Graft vs Host Disease / epidemiology
  • Graft vs Host Disease / etiology
  • Granulocyte Colony-Stimulating Factor / adverse effects
  • Granulocyte Colony-Stimulating Factor / pharmacology
  • Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
  • Hematopoietic Stem Cell Mobilization / adverse effects
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / methods*
  • Hematopoietic Stem Cell Transplantation / mortality
  • Hematopoietic Stem Cells*
  • Humans
  • Immunophenotyping
  • Leukapheresis
  • Leukocyte Count
  • Liver / cytology
  • Liver / embryology
  • Lymphocyte Activation
  • Monocytes / drug effects
  • Monocytes / physiology
  • Multicenter Studies as Topic
  • Neutrophils / cytology
  • Organ Specificity
  • Platelet Count
  • Randomized Controlled Trials as Topic
  • Recombinant Proteins / pharmacology
  • Registries
  • Retrospective Studies
  • T-Lymphocyte Subsets / immunology
  • Tissue Donors
  • Tissue and Organ Procurement / methods
  • Transplantation, Homologous

Substances

  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Filgrastim