Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*0314

Tissue Antigens. 2001 Sep;58(3):205-6. doi: 10.1034/j.1399-0039.2001.580313.x.

Abstract

We describe the identification of a new DRB1*03 variant in a Caucasian volunteer bone-marrow donor (DR'KW'). The indication for the existence of this new variant arose from contradictory results obtained by serological and several DNA typing methods (SSP, SSOP). Analysis of the exon 2 sequence revealed that the DRB1*0314 contained the characteristic DR3 specific sequence motifs, except for codon 77 (AAC-->ACC) where threonine is substituted for asparagine.

MeSH terms

  • Alleles*
  • Amino Acid Motifs
  • Amino Acid Substitution
  • Base Sequence
  • Bone Marrow Transplantation
  • Codon
  • Exons
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Histocompatibility Testing
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Genetic
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Threonine / genetics
  • Tissue Donors

Substances

  • Codon
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • Threonine

Associated data

  • GENBANK/Y17863