Abstract
The dopamine transporter is a plasma membrane protein that controls the spatial and temporal domains of dopamine neurotransmission through the accumulation of extracellular dopamine. The dopamine transporter may play a role in numerous dopamine-linked neuropsychiatric disorders. We review the cloning and organization of the human dopamine transporter gene, polymorphisms in its coding and noncoding sequence, and emerging data on its transcriptional regulation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Base Sequence
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Dopamine / genetics
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Dopamine / metabolism*
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Dopamine Plasma Membrane Transport Proteins
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Gene Order / genetics*
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Humans
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Membrane Glycoproteins*
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Membrane Transport Proteins / biosynthesis
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Membrane Transport Proteins / chemistry
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Membrane Transport Proteins / genetics*
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Mental Disorders / genetics*
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Mental Disorders / metabolism
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Molecular Sequence Data
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Nerve Tissue Proteins*
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Transcription, Genetic / genetics*
Substances
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Dopamine