Treatment of idiopathic restless legs syndrome (RLS) with gabapentin

S Happe; G Klösch; B Saletu; J Zeitlhofer

doi:10.1212/wnl.57.9.1717

Treatment of idiopathic restless legs syndrome (RLS) with gabapentin

Neurology. 2001 Nov 13;57(9):1717-9. doi: 10.1212/wnl.57.9.1717.

Authors

S Happe¹, G Klösch, B Saletu, J Zeitlhofer

Affiliation

¹ Department of Clinical Neurology, University of Vienna, Austria. [email protected]

PMID: 11706121
DOI: 10.1212/wnl.57.9.1717

Abstract

Nine patients with idiopathic restless legs syndrome (RLS) were treated with 300 mg of gabapentin as an initial dose and an up-titration until relief of symptoms for 4 weeks. Subjective symptoms improved significantly. Polysomnographic data showed a reduction of periodic leg movements during sleep (PLMS) (p = 0.003) and PLMS index (p = 0.001). The authors conclude that gabapentin provides a well-tolerated and effective treatment of idiopathic RLS.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Acetates / administration & dosage*
Acetates / adverse effects
Aged
Amines*
Anticonvulsants / administration & dosage*
Anticonvulsants / adverse effects
Cyclohexanecarboxylic Acids*
Female
Gabapentin
Humans
Male
Middle Aged
Polysomnography
Restless Legs Syndrome / drug therapy*
gamma-Aminobutyric Acid*

Substances

Acetates
Amines
Anticonvulsants
Cyclohexanecarboxylic Acids
gamma-Aminobutyric Acid
Gabapentin