Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes

Y Mikata; Y Shinohara; K Yoneda; Y Nakamura; I Brudziñska; T Tanase; T Kitayama; R Takagi; T Okamoto; I Kinoshita; M Doe; C Orvig; S Yano

doi:10.1016/s0960-894x(01)00623-0

Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3045-7. doi: 10.1016/s0960-894x(01)00623-0.

Authors

Y Mikata¹, Y Shinohara, K Yoneda, Y Nakamura, I Brudziñska, T Tanase, T Kitayama, R Takagi, T Okamoto, I Kinoshita, M Doe, C Orvig, S Yano

Affiliation

¹ KYOUSEI Science Center, Nara Women's University, Nara 630-8506, Japan. [email protected]

PMID: 11714607
DOI: 10.1016/s0960-894x(01)00623-0

Abstract

Eight carbohydrate-pendant platinum(II) complexes have been synthesized from carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xylose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the carbohydrate moieties reduced the toxicity inherent with platinum(II) complexes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Carbohydrate Metabolism*
Carbohydrates / chemistry
Carbohydrates / pharmacology*
Cisplatin / chemistry
Cisplatin / pharmacology*
Drug Screening Assays, Antitumor
Lethal Dose 50
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred Strains
Molecular Structure
Organoplatinum Compounds / chemistry*
Organoplatinum Compounds / pharmacology*

Substances

2-glucose-diaminopropane-dichloroplatinum(II)
Antineoplastic Agents
Carbohydrates
Organoplatinum Compounds
Cisplatin