Objective: To investigate the change of respiratory and circulatory function in COPD during sequential invasive-noninvasive mechanical ventilation.
Methods: 12 COPD patients with type II respiratory failure were ventilated via endotracheal intubation. When pulmonary infection was under control (the appearance of "PIC Window"), all patients were extubated and received mask ventilation. The parameters of hemodynamics oxygenation and esophageal pressure were measured during endotracheal ventilation and mask ventilation (3 hrs after extubation).
Results: The change of respiratory and circulatory parameters were not significantly different between invasive mechanical ventilation and noninvasive mechanical ventilation (P > 0.05).
Conclusion: The respiratory and circulatory function of COPD patients remained stable during sequential invasive-noninvasive mechanical ventilation.