Abstract
In four patients with acute basilar artery thrombosis, complete arterial recanalization and good neurologic outcome were achieved with a treatment combining alteplase with tirofiban. In no cases were cerebral or extracerebral hemorrhagic complications observed. Combined fibrinolytic agents and glycoprotein IIb/IIIa inhibitors may have high potential in the treatment of acute cerebrovascular thrombosis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Basilar Artery*
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Drug Therapy, Combination
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Female
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Fibrinolytic Agents / administration & dosage*
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Humans
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Male
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Middle Aged
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Platelet Aggregation Inhibitors / administration & dosage*
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Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
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Thrombosis / drug therapy*
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Tirofiban
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Tissue Plasminogen Activator / administration & dosage*
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Tyrosine / administration & dosage*
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Tyrosine / analogs & derivatives*
Substances
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Fibrinolytic Agents
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Platelet Aggregation Inhibitors
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Platelet Glycoprotein GPIIb-IIIa Complex
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Tyrosine
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Tissue Plasminogen Activator
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Tirofiban