Abstract
Fenhexamid, a recently developed botryticide, is shown here to inhibit sterol biosynthesis. When the fungus Botryotinia fuckeliana was grown in the presence of fenhexamid, the ergosterol content was reduced, and three 3-keto compounds, 4 alpha-methylfecosterone, fecosterone and episterone, accumulated, suggesting an inhibition of the 3-keto reductase involved in C-4 demethylation. Thus, fenhexamid belongs to a new, promising class of sterol biosynthesis inhibitors not previously used in agriculture or in medicine.
MeSH terms
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Amides / chemistry
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Amides / metabolism
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Amides / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / metabolism
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Antifungal Agents / pharmacology
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Botrytis / drug effects*
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Botrytis / growth & development
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Botrytis / metabolism
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Cell Wall / drug effects
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Fungicides, Industrial / chemistry
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Fungicides, Industrial / metabolism
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Fungicides, Industrial / pharmacology*
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Molecular Structure
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Phytosterols / antagonists & inhibitors
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Phytosterols / biosynthesis*
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Plant Diseases / microbiology*
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Structure-Activity Relationship
Substances
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Amides
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Antifungal Agents
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Fungicides, Industrial
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Phytosterols
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N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide