Analogues of androgen hormones with inverted configuration at carbons 5, 9, and 10

Steroids. 2002 Jan;67(1):57-70. doi: 10.1016/s0039-128x(01)00135-0.

Abstract

On catalytic hydrogenation of Delta(9)-steroids (e.g. 3beta-hydroxy-5-methyl-19-nor-5beta-androst-9-en-17-one), four isomers were formed: 9alpha,10alpha-, 9alpha,10beta-, 9beta,10alpha- and 9beta,10beta-adducts. The product distribution was affected by the nature of the C-3 substituent. A chair conformation of A, B, and C rings was found in all of the products with the exception of the 9alpha,10alpha-adduct whose B ring adopts a twist boat conformation. The products were utilized for the synthesis of dihydrotestosterone analogues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androgens / chemical synthesis*
  • Androgens / chemistry*
  • Carbon / chemistry*
  • DNA Adducts
  • Dihydrotestosterone / chemical synthesis
  • Dihydrotestosterone / chemistry
  • Hydrogen / chemistry
  • Isomerism
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Protein Conformation
  • Steroids / chemical synthesis*
  • Steroids / chemistry*

Substances

  • Androgens
  • DNA Adducts
  • Steroids
  • Dihydrotestosterone
  • Carbon
  • Hydrogen