Somatostatin- and Substance P-ergic neurons and Glial cell line-derived neurotrophic factor in the human archicortex

Ital J Anat Embryol. 2001;106(2 Suppl 1):459-65.

Abstract

By means of immunohistochemistry, the localization of Somatostatin (SOM)- and Substance P (SP)-ergic neuronal populations was compared to the occurrence of Glial cell line-derived neurotrophic factor (GDNF) in the human hippocampus from prenatal to adult life stages. The results obtained i) confirm previous reports on the distribution of SOM and SP; ii) show that GDNF-like immunoreactivity occurs in an ample population of hippocampal neurons, with a main location in the pyramidal cells; iii) identify regions of codistribution of either neuropeptide with GDNF-positive elements. Although coexistence of GDNF with SOM or SP was not detected, the possibility that the trophic factor may act on the neuropeptide-containing neurons can be envisaged and is worth further analysis.

MeSH terms

  • Adult
  • Aging / metabolism*
  • Cell Differentiation / physiology*
  • Fetus
  • Glial Cell Line-Derived Neurotrophic Factor
  • Hippocampus / embryology*
  • Hippocampus / growth & development*
  • Hippocampus / metabolism
  • Humans
  • Immunohistochemistry
  • Infant, Newborn
  • Nerve Growth Factors*
  • Nerve Tissue Proteins / metabolism*
  • Presynaptic Terminals / metabolism
  • Presynaptic Terminals / ultrastructure
  • Pyramidal Cells / cytology
  • Pyramidal Cells / metabolism*
  • Somatostatin / metabolism*
  • Substance P / metabolism*

Substances

  • GDNF protein, human
  • Glial Cell Line-Derived Neurotrophic Factor
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Substance P
  • Somatostatin