Abstract
In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7. In the absence of IL-7, T-cell reactivity to MOG and MBP was similar in MS patients and controls even if an increased MBP response was found in a subgroup of patients with active disease. In the presence of IL-7, increased T-cell reactivity to MBP was observed in MS patients suggesting that their MBP-specific T cells are in a different functional state.
MeSH terms
-
Adult
-
Aged
-
Aged, 80 and over
-
Female
-
Humans
-
In Vitro Techniques
-
Interleukin-7 / pharmacology*
-
Male
-
Middle Aged
-
Multiple Sclerosis, Chronic Progressive / immunology*
-
Multiple Sclerosis, Relapsing-Remitting / immunology*
-
Myelin Basic Protein / immunology
-
Myelin Basic Protein / pharmacology*
-
Myelin Proteins
-
Myelin-Associated Glycoprotein / immunology
-
Myelin-Associated Glycoprotein / pharmacology*
-
Myelin-Oligodendrocyte Glycoprotein
-
T-Lymphocytes / drug effects
-
T-Lymphocytes / immunology*
Substances
-
Interleukin-7
-
MOG protein, human
-
Myelin Basic Protein
-
Myelin Proteins
-
Myelin-Associated Glycoprotein
-
Myelin-Oligodendrocyte Glycoprotein