Abstract
The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid
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Analgesics / administration & dosage
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Analgesics / pharmacology*
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Analgesics / therapeutic use
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Animals
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Asteraceae*
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Dose-Response Relationship, Drug
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Lactones / administration & dosage
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Lactones / pharmacology*
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Lactones / therapeutic use
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Male
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Mice
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Pain / chemically induced
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Pain / prevention & control*
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Pain Measurement / drug effects*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Sesquiterpenes / administration & dosage
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Sesquiterpenes / pharmacology*
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Sesquiterpenes / therapeutic use
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Sesquiterpenes, Germacrane*
Substances
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Analgesics
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Lactones
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Plant Extracts
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Sesquiterpenes
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Sesquiterpenes, Germacrane
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deoxymikanolide
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Acetic Acid