In vitro susceptibility of clinical isolates of Zygomycota to amphotericin B, flucytosine, itraconazole and voriconazole

A Gómez-López; M Cuenca-Estrella; A Monzón; J L Rodriguez-Tudela

doi:10.1093/jac/48.6.919

In vitro susceptibility of clinical isolates of Zygomycota to amphotericin B, flucytosine, itraconazole and voriconazole

J Antimicrob Chemother. 2001 Dec;48(6):919-21. doi: 10.1093/jac/48.6.919.

Authors

A Gómez-López¹, M Cuenca-Estrella, A Monzón, J L Rodriguez-Tudela

Affiliation

¹ Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2, 28220 Majadahonda, Madrid, Spain.

PMID: 11733480
DOI: 10.1093/jac/48.6.919

Abstract

The in vitro susceptibility of 29 clinical isolates of fungi belonging to the division Zygomycota was reviewed. A broth microdilution test was performed by following the NCCLS reference method, with minor modifications. The species of Zygomycota tested were resistant in vitro to flucytosine, itraconazole and voriconazole. Amphotericin B showed the best activity against most of the strains evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / pharmacology
Antifungal Agents / pharmacology*
Flucytosine / pharmacology
Fungi / drug effects*
Fungi / growth & development
Fungi / isolation & purification*
Humans
Itraconazole / pharmacology
Microbial Sensitivity Tests / methods
Pyrimidines / pharmacology
Triazoles / pharmacology
Voriconazole

Substances

Antifungal Agents
Pyrimidines
Triazoles
Itraconazole
Amphotericin B
Flucytosine
Voriconazole