Successful treatment of foscarnet-resistant herpes simplex stomatitis with intravenous cidofovir in a child

Pediatr Infect Dis J. 2001 Nov;20(11):1083-6. doi: 10.1097/00006454-200111000-00016.

Abstract

A leukemic child developed recurrent herpes simplex virus lesions shortly after receiving a bone marrow transplant and while taking acyclovir. The isolate was resistant to acyclovir and foscarnet in vitro. The lesions responded to a course of cidofovir.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / administration & dosage
  • Acyclovir / pharmacology
  • Acyclovir / therapeutic use
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use*
  • Bone Marrow Transplantation / immunology
  • Child
  • Cidofovir
  • Cytosine / administration & dosage
  • Cytosine / analogs & derivatives*
  • Cytosine / pharmacology
  • Cytosine / therapeutic use*
  • Drug Resistance, Multiple, Viral
  • Female
  • Foscarnet / pharmacology
  • Foscarnet / therapeutic use
  • Herpes Simplex / drug therapy*
  • Herpes Simplex / pathology
  • Herpes Simplex / virology
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 1, Human / growth & development
  • Humans
  • Immunocompromised Host
  • Injections, Intravenous
  • Organophosphonates*
  • Organophosphorus Compounds / administration & dosage
  • Organophosphorus Compounds / pharmacology
  • Organophosphorus Compounds / therapeutic use*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery
  • Recurrence
  • Stomatitis / drug therapy*
  • Stomatitis / pathology
  • Stomatitis / virology

Substances

  • Antiviral Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Foscarnet
  • Cytosine
  • Cidofovir
  • Acyclovir