Abstract
We studied long-term outcome (range, 28-89 months; mean, 56 months) after multiple subpial transections (MSTs) for medically refractory epilepsy. Forty-three (79.6%) of 54 patients had a consistent significant reduction in seizure frequency, and 27 (50%) of the 54 were either entirely seizure free or virtually so. However, 10 (18.6%) patients sustained an increase in seizure frequency several years after surgery, after showing initial postoperative improvement. This suggests that late seizure recurrence is a more important problem in cases in which MST has been performed than for pure resections.
MeSH terms
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Axons / pathology
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Axons / physiology
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Brain Mapping
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology
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Cerebral Cortex / surgery*
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Dominance, Cerebral / physiology
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Electroencephalography
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Epilepsy / diagnosis
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Epilepsy / physiopathology
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Epilepsy / surgery*
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Follow-Up Studies
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Humans
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Motor Cortex / pathology
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Motor Cortex / physiopathology
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Motor Cortex / surgery
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Postoperative Complications / etiology*
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Postoperative Complications / pathology
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Postoperative Complications / physiopathology
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Recurrence
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Somatosensory Cortex / pathology
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Somatosensory Cortex / physiopathology
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Somatosensory Cortex / surgery