Endokeratoplasty using an infant donor cornea was performed in an 81-year-old man with Fuchs' endothelial dystrophy, corneal decompensation, and a history of cystoid macular edema in the left eye. The patient reported minimal discomfort after surgery, and the best spectacle-corrected visual acuity improved from 20/400 to 20/100 by the second postoperative month with resolution of the corneal edema. Endokeratoplasty using an infant cornea is a viable alternative to penetrating keratoplasty for corneal endothelial decompensation, and infant corneas may provide a new and potentially healthier source of tissue for corneal transplantation.