A double-blind, parallel-group study of amlodipine versus long-acting nitrate in the management of elderly patients with stable angina

Cardiology. 2001;96(2):72-7. doi: 10.1159/000047392.

Abstract

Ninety-seven elderly patients with stable angina were included in a 28-week, randomized, double-blind, parallel-group comparison of amlodipine 5-10 mg and isosorbide mononitrate 25-50 mg once daily. The total exercise time, as limited by angina, was recorded together with the median incidence per week of angina attacks and glyceryl trinitrate consumption. Safety was assessed by adverse event frequency, measurement of vital signs and laboratory parameters, and quality of life. At the final visit, the total exercise time was significantly greater relative to baseline with amlodipine than isosorbide mononitrate (final/baseline difference: 112.2 vs. 32.2, p = 0.016). There were no statistically significant differences between the groups in relation to the incidence of adverse events. Once daily amlodipine provides significantly better control of stable angina than isosorbide mononitrate in this elderly population.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amlodipine / administration & dosage
  • Amlodipine / adverse effects
  • Amlodipine / therapeutic use*
  • Angina Pectoris / drug therapy*
  • Angina Pectoris / physiopathology
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Calcium Channel Blockers / administration & dosage
  • Calcium Channel Blockers / adverse effects
  • Calcium Channel Blockers / therapeutic use*
  • Delayed-Action Preparations / administration & dosage
  • Delayed-Action Preparations / adverse effects
  • Delayed-Action Preparations / therapeutic use
  • Double-Blind Method
  • Edema / chemically induced
  • Exercise Test / drug effects
  • Exercise Tolerance / drug effects
  • Exercise Tolerance / physiology
  • Female
  • Headache / chemically induced
  • Heart Rate / drug effects
  • Heart Rate / physiology
  • Humans
  • Isosorbide Dinitrate / administration & dosage
  • Isosorbide Dinitrate / adverse effects
  • Isosorbide Dinitrate / analogs & derivatives
  • Isosorbide Dinitrate / therapeutic use*
  • Male
  • Middle Aged
  • Nitroglycerin / therapeutic use
  • Quality of Life
  • Time Factors
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / adverse effects
  • Vasodilator Agents / therapeutic use*

Substances

  • Calcium Channel Blockers
  • Delayed-Action Preparations
  • Vasodilator Agents
  • Amlodipine
  • Nitroglycerin
  • Isosorbide Dinitrate
  • isosorbide-5-mononitrate