Small changes in expression affect predisposition to tumorigenesis

Hai Yan; Zuzana Dobbie; Stephen B Gruber; Sanford Markowitz; Kathy Romans; Francis M Giardiello; Kenneth W Kinzler; Bert Vogelstein

doi:10.1038/ng799

Small changes in expression affect predisposition to tumorigenesis

Nat Genet. 2002 Jan;30(1):25-6. doi: 10.1038/ng799. Epub 2001 Dec 17.

Authors

Hai Yan¹, Zuzana Dobbie, Stephen B Gruber, Sanford Markowitz, Kathy Romans, Francis M Giardiello, Kenneth W Kinzler, Bert Vogelstein

Affiliation

¹ The Howard Hughes Medical Institute, The Oncology Center, and The Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

PMID: 11743581
DOI: 10.1038/ng799

Abstract

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adenoma / genetics*
Adenomatous Polyposis Coli / genetics*
Alleles
Cell Transformation, Neoplastic / genetics*
DNA, Complementary / genetics
DNA, Neoplasm / genetics
Gene Expression Regulation*
Genes, APC*
Genetic Predisposition to Disease
Humans
Loss of Heterozygosity
Polymerase Chain Reaction
Templates, Genetic

Substances

DNA, Complementary
DNA, Neoplasm