Abstract
These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and systemic) have the ability to produce eicosanoids both from simple metabolites and from arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids represent a potential class of novel virulence factors.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Cysteine / biosynthesis*
-
Dinoprost / biosynthesis*
-
Dinoprostone / biosynthesis*
-
Leukotriene B4 / biosynthesis*
-
Leukotrienes / biosynthesis*
-
Mitosporic Fungi / growth & development
-
Mitosporic Fungi / metabolism*
-
Mucorales / growth & development
-
Mucorales / metabolism*
-
Prostaglandin D2 / biosynthesis*
Substances
-
Leukotrienes
-
cysteinyl-leukotriene
-
Leukotriene B4
-
Dinoprost
-
Dinoprostone
-
Cysteine
-
Prostaglandin D2