Unraveling resistance to trastuzumab (Herceptin): insulin-like growth factor-I receptor, a new suspect

J Natl Cancer Inst. 2001 Dec 19;93(24):1830-2. doi: 10.1093/jnci/93.24.1830.
No abstract available

Publication types

  • Comment
  • Editorial

MeSH terms

  • Antibodies, Monoclonal / pharmacology*
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents / pharmacology*
  • Breast Neoplasms / drug therapy
  • Cell Cycle Proteins / metabolism
  • Cyclin-Dependent Kinase Inhibitor p27
  • Drug Resistance, Neoplasm*
  • Humans
  • Receptor, ErbB-2 / metabolism
  • Receptor, IGF Type 1 / metabolism*
  • Signal Transduction
  • Trastuzumab
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins / metabolism

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Cell Cycle Proteins
  • Tumor Suppressor Proteins
  • Cyclin-Dependent Kinase Inhibitor p27
  • Receptor, ErbB-2
  • Receptor, IGF Type 1
  • Trastuzumab