Abstract
Chemical investigation of the Australian rainforest plant Doryphora sassafras has resulted in the isolation of a new natural product, 2-methyl-1-(p-methoxybenzyl)-6,7-methylenedioxyisoquinolinium chloride (1). The iodide salt of compound 1 has previously been synthesized but only partially characterized. This paper reports the full spectroscopic characterization of 1 by MS, IR, UV, and NMR data.
MeSH terms
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification*
-
Alkaloids / pharmacology
-
Analgesics, Opioid / chemistry
-
Analgesics, Opioid / isolation & purification*
-
Analgesics, Opioid / pharmacology
-
Animals
-
Australia
-
Brain / drug effects
-
Cell Membrane / drug effects
-
Cerebellum / drug effects
-
Guinea Pigs
-
Inhibitory Concentration 50
-
Isoquinolines / chemistry
-
Isoquinolines / isolation & purification*
-
Isoquinolines / pharmacology
-
Mass Spectrometry
-
Molecular Structure
-
Monimiaceae / chemistry*
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Leaves / chemistry
-
Plants, Medicinal / chemistry*
-
Quinolinium Compounds*
-
Receptors, Opioid, kappa / physiology
-
Spectrophotometry, Infrared
-
Spectrophotometry, Ultraviolet
Substances
-
2-methyl-1-(p-methoxybenzyl)-6,7-methylenedioxyisoquinolinium
-
Alkaloids
-
Analgesics, Opioid
-
Isoquinolines
-
Quinolinium Compounds
-
Receptors, Opioid, kappa