Seven indexes were used to study the landscape heterogeneity of vegetation in Guangzhou City. The results show that the patch density was 11.8 patches.km-2 and the line corridor density was 1.87 km.km-2. In old urban area, the vegetation landscape was characterized by small patches, heavy fragmentation, high diversity and random distribution, showing a highly heterogeneous spatial pattern, while in new urban area, the vegetation landscape was characterized by big patches and even distribution. Therefore, when the size of vegetation area was the same, the even distribution of vegetation could improve the landscape heterogeneity and make the ecological function more effective.