Clinical characteristics of 25 cases of otogenic and 26 cases of rhinosinusogenic sepsis have been analysed. The main diagnostic criteria of the sepsis were the following: fever, leukocytosis, micro- and macrovascular abnormalities, respiratory and coagulation disorders, abnormal protein levels in plasma, etc. Oto- and rhinosinusogenic sepsis in 45(88.2%) examinees was associated with intracranial complications. Early diagnosis of sepsis, timely operation after adequate preparation, administration of antimicrobial drugs and infusions, stay of patients in intensive care unit with permanent monitoring provided a good outcome in 94% patients.